Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Eflornithine hydrochloride68278-23-9HY-B0744A218.63C6H13ClF2N2O2>98%Solubility:DMSOMechanisms: Pathways:Others; Target:Others gyBiological Activity:Eflornithine hydrochloride (DFMO hydrochloride) is a drug found to be effective in the treatment offacial hirsutism. Target: Others Eflornithine is a \"suicide inhibitor,\" irreversibly binding to Ornithine Decarboxylase (ODC) andpreventing the natural substrate ornithine from accessing the active site. Within the active site ofODC, eflornithine undergoes decarboxylation with aid of the cofactor pyridoxal 5'-phosphate (PLP).Because of its additional difluoromethyl group in comparison to ornithine, eflornithine is able to bindto a neighboring Cys-360 residue, permanently remaining fixated within the active site.ggypyg ...References:[1]. http://en.wikipedia.org/wiki/Eflornithine Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
