专利内容由知识产权出版社提供
专利名称：COMPOSITIONS AND METHODS RELATING
TO C5L2
发明人：Claudia Kemper,Cedric Francois,Pascal
Deschatelets,Monica Gerber
申请号：US14910833申请日：20140808
公开号：US20160271216A1公开日：20160922
摘要：In some aspects, provided herein is a method of enhancing production ofinterleukin-17 (IL-17), interferon gamma (IFN-γ), or both by a mammalian T cell, themethod comprising contacting the cell with a C5L2 inhibitor. In some aspects, providedherein is a method of enhancing Th1 and/or Th17 responses by a mammalian T cell, themethod comprising contacting the cell with a C5L2 inhibitor. In some aspects, providedherein is a method of enhancing production of interleukin-6 (IL-6), interleukin 1 beta (IL-Iβ), or both by a mammalian T cell or monocyte, the method comprising contacting thecell with a C5L2 inhibitor. In some aspects, provided herein is a method of decreasingsuppressive activity of a T regulatory cell, e.g., a natural regulatory T (nTreg) cell, themethod comprising contacting a Treg cell, e.g., an nTreg cell, with an inhibitor of C5L2.
申请人：KING'S COLLEGE LONDON,APELLIS PHARMACEUTICALS, INC.
地址：London GB,Crestwood KY US
国籍：GB,US
更多信息请下载全文后查看
