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专利名称：Method of using adenoviral vectors with
increased persistence in vivo
发明人：Thomas J. Wickham,Masaki Akiyama,Jason
G.D. Gall
申请号：US11208405申请日：20050819
公开号：US20060140909A1公开日：20060629
摘要：The invention provides a method of expressing an exogenous nucleic acid in amammal. The method comprises slowly releasing into the bloodstream a dose ofreplication-deficient or conditionally-replicating adenoviral vector having reduced abilityto transduce mesothelial cells and hepatocytes. The normalized average bloodstreamconcentration of the adenovirus over 24 hours post-administration is at least about 1%.Alternatively, the normalized average bloodstream concentration over 24 hours post-administration is at least about 5-fold greater than the normalized average bloodstreamconcentration for an equivalent dose of a wild-type adenoviral vector. A method ofdestroying tumor cells in a mammal also is provided, as is a replication-deficientadenoviral vector comprising a serotype 5 or serotype 35 adenoviral genome with aserotype 41 fiber protein, wherein the replication-deficient adenoviral vector exhibitsreduced native binding to integrins.
申请人：Thomas J. Wickham,Masaki Akiyama,Jason G.D. Gall
地址：Billerica MA US,Gaithersburg MD US,Germantown MD US
国籍：US,US,US
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