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专利名称：Methods of delivering a physiologically
active polypeptide to a mammal
发明人：Philip L. Felgner,Jon Asher Wolff,Gary H.
Rhodes,Robert Wallace Malone,Dennis A.Carson
申请号：US09449923申请日：19991202公开号：US013942B1公开日：20020702
摘要：A method for delivering an isolated polynucleotide to the interior of a cell in avertebrate, comprising the interstitial introduction of an isolated polynucleotide into atissue of the vertebrate where the polynucleotide is taken up by the cells of the tissueand exerts a therapeutic effect on the vertebrate. The method can be used to deliver atherapeutic polypeptide to the cells of the vertebrate, to provide an immune responseupon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, todeliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
申请人：VICAL, INC.,WISCONSIN ALUMNI RESEARCH FOUNDATION
代理机构：Sterne, Kessler, Goldtein & Fox P.L.L.C.
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