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专利名称：Methods and apparatuses for analyzing
biological samples by mass spectrometry
发明人：Caprioli, Richard申请号：EP10183126.1申请日：20020918公开号：EP2277615A2公开日：20110126
专利附图：
摘要：The present invention provides a method for classifying disease. The methodcomprises the following steps: (a) generating a diseased specimen including an energyabsorbent matrix; (b) striking the specimen with a laser beam such that a predetermined
first laser spot on the specimen releases first sample proteins; (c) measuring the atomicmass of the released first sample proteins over a range of atomic masses; (d) moving thespecimen relative to the laser beam a predetermined linear distance functionally relatedto a size of the predetermined first laser spot; (e) striking the specimen with the laserbeam such that a predetermined second laser spot on the specimen releases secondsample proteins; (f) measuring the atomic mass of the released second sample proteinsover a range of atomic masses; (g) analyzing an atomic mass window of interest within therange of atomic masses to determine the spatial arrangement of specific proteins withinthe sample; (h) identifying the specific proteins as a function of the spatial arrangement;and (i) correlating the identified specific proteins with one or more diseases to classify thediseased specimen.
申请人：VANDERBILT UNIVERSITY
地址：Box 6009 Station B Nashville, TN 37235 US
国籍：US
代理机构：Dehmel, Albrecht
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