Product Data SheetProduct Name:CAS No.: CatNo:Cat. No.:MWt:Formula:Purity :Flunixin meglumine42461-84-7HYB0386HY-B031.46C21H28F3N3O7>98%Solubility:DMSO99mg/mL;Water99mg/mLDMSO 99 mg/mL; Water 99 mg/mLMechanisms: Pathways:Immunology/Inflammation; Target:COX Biological Activity:Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory andantipyretic activity. Target: COX Flunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatoryand antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin megluminetherapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs ofinflammation and improved clinically graded depression when compared with these signs in salinesolution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. CarprofeninhibitedLPSinductionofiNOSCarprofenandtoalesserdegreeflunixinmegluminehadinhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine hadinhibitory effects on NFκB activation [2]. ...References:[1]. Anderson, K.L., et al., Efficacy of flunixin meglumine for the treatment of endotoxin-inducedbovine mastitis. Am J Vet Res, 1986. 47(6): p. 1366-72. [2]. Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixinmegluminetoinhibitactivationofnuclearfactorkappaBAmJVetRes2003(2):p2115 meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. (2): p. 211-5.Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
