专利内容由知识产权出版社提供
专利名称：METHODS AND KITS FOR DETECTING RISK
FACTORS FOR DEVELOPMENT OF JAWOSTEONECROSIS AND METHODS OFTREATMENT THEREOF
发明人：KATZ, Joseph,LANGAEE, Taimour申请号：EP09795044.8申请日：20090707公开号：EP2307576A1公开日：20110413
摘要：Determining the pharmacogenetic, pharmacokinetic and cellular basis ofbisphosphonate-induced osteonecrosis of the jaw (BONJ) via associating particularproteins and particular single nucleotide polymorphisms with a risk for developing BONJafter receiving bisphosphonate treatment. Methods and kits for identifying the geneticbasis for a patient's predisposition to BONJ. A haplotype tagging SNP approach was usedto analyze candidate genes involved in bone absorption and destruction and to examinethe influence of genetic variants on the susceptibility of BONJ. Bone biomarkers of BONJare disclosed. Said biomarkers provide for improved monitoring of the drugs used totreat BONJ, improved prevention of BONJ, and optimized treatment of patients havingBONJ or predisposed to BONJ.
申请人：University of Florida Research Foundation, Inc.
地址：223 Grinter Hall Gainesville, FL 32611 US
国籍：US
代理机构：Jappy, John William Graham
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