Biodegradable polyketal polymers and methods for t

专利名称：Biodegradable polyketal polymers and

methods for their formation and use

发明人：Mikhail I. Papisov申请号：US12620855申请日：20091118公开号：US07951898B2公开日：20110531

专利附图：

摘要：The present invention relates to biodegradable biocompatible polyketals,methods for their preparation, and methods for treating animals by administration ofbiodegradable biocompatible polyketals. In one aspect, a method for forming the

biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizingagent with a polysaccharide to form an aldehyde intermediate, which is combined with areducing agent to form the biodegradable biocompatible polyketal. The resultantbiodegradable biocompatible polyketals can be chemically modified to incorporateadditional hydrophilic moieties. A method for treating animals includes the administrationof the biodegradable biocompatible polyketal in which biologically active compounds ordiagnostic labels can be disposed. The present invention also relates to chiral polyketals,methods for their preparation, and methods for use in chromatographic applications,specifically in chiral separations. A method for forming the chiral polyketals comprisescombining a glycol-specific oxidizing agent with a polysaccharide to form an aldehydeintermediate, which is combined with a suitable reagent to form the chiral polyketal. Amethod for use in chiral separations includes the incorporation of the chiral polyketals inthe mobile phase during a chromatographic separation, or into chiral stationary phasessuch as gels. The present invention further relates to chiral polyketals as a source forchiral compounds, and methods for generating such chiral compounds.

申请人：Mikhail I. Papisov

地址：Winchester MA US

国籍：US

代理机构：Choate, Hall & Stewart LLP

代理人：Brenda Herschbach Jarrell,Kristen C. Buteau

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